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Pulmonary embolism (PE) is the leading trigger of in-hospital death and the third most frequent cause of cardiovascular loss of life. The clinical presentation of PE is variable, and choosing the appropriate treatment for individual patients could be challenging. Traditionally, treatment of PE has involved a selection of anticoagulation, thrombolysis or surgery; nevertheless, a variety of percutaneous interventional applied sciences have been developed which can be underneath investigation in patients with intermediate-excessive-risk or high-danger PE. These interventional applied sciences embody catheter-directed thrombolysis (with or with out ultrasound assistance), aspiration thrombectomy and mixtures of the aforementioned ideas. These interventional therapy options might lead to a more rapid improvement in right ventricular perform and pulmonary and/or systemic haemodynamics particularly patients.